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What is ondansetron hydrochloride?

2025-11-25 01:29:30 healthy

What is ondansetron hydrochloride?

Recently, Ondansetron Hydrochloride has become a hot topic due to its wide application in the medical field. This article will give you a detailed introduction to the definition, uses, side effects and market trends of ondansetron hydrochloride based on the hot content on the Internet in the past 10 days.

1. Definition of ondansetron hydrochloride

What is ondansetron hydrochloride?

Ondansetron hydrochloride is a5-HT3 receptor antagonist, mainly used to prevent and treat nausea and vomiting caused by chemotherapy, radiotherapy or surgery. It reduces the triggering of the gag reflex by blocking 5-HT3 receptors in the intestines and central nervous system.

Projectcontent
chemical nameOndansetron hydrochloride
Molecular formulaC18H19N3O·HCl
IndicationsChemotherapy/radiation therapy-related nausea and vomiting, postoperative nausea and vomiting
Dosing methodOral, intravenous, orally dissolving tablets

2. Recent hot application scenarios

1.COVID-19 related vomiting treatment: Some studies show it may relieve gastrointestinal symptoms in COVID-19 patients.
2.Morning sickness management: Multinational guidelines recommend it for the second-line treatment of hyperemesis gravidarum.
3.Pediatric applications: Becoming one of the first-choice drugs for antiemetics during chemotherapy in children.

Application areasUsage proportion (2023 data)
Cancer Chemotherapy68%
Postoperative recovery22%
Other uses10%

3. Side effects and precautions

According to the latest FDA warning:
- may causeQT interval prolongation, patients with heart disease should use with caution
- Common side effects include headache (15%), constipation (9%)
- Concomitant use with apomorphine may reduce the efficacy of the drug

adverse reactionsincidence
headache15%-18%
constipation8%-10%
Lethargy5%-7%

4. Market dynamics (hot spots in the past 10 days)

1.generic competition: A total of 12 domestic companies have passed the consistency evaluation
2.price fluctuations: The average price of 4mg tablets dropped to 2.3 yuan/tablet
3.Research and development of new dosage forms: Transdermal patch enters clinical phase III trial

Manufacturing companymarket share
Hengrui Medicine31%
Qilu Pharmaceutical25%
It's sunny18%

5. Medication Guide

Standard dosage:
-before chemotherapy:8mg intravenous injection
-maintenance dose: 8 mg orally every 8 hours
Special groups:
- Patients with hepatic insufficiency need to reduce the dose by half
- No dose adjustment required in the elderly

Summary: Ondansetron hydrochloride, as a highly effective antiemetic, plays a key role in tumor treatment and other fields. The recent expansion of its application scope and the development of new dosage forms continue to attract attention, but the risk of cardiovascular side effects needs to be paid attention to when using the drug. It is recommended that patients use it under the guidance of a doctor.

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