What is ondansetron hydrochloride?
Recently, Ondansetron Hydrochloride has become a hot topic due to its wide application in the medical field. This article will give you a detailed introduction to the definition, uses, side effects and market trends of ondansetron hydrochloride based on the hot content on the Internet in the past 10 days.
1. Definition of ondansetron hydrochloride
Ondansetron hydrochloride is a5-HT3 receptor antagonist, mainly used to prevent and treat nausea and vomiting caused by chemotherapy, radiotherapy or surgery. It reduces the triggering of the gag reflex by blocking 5-HT3 receptors in the intestines and central nervous system.
| Project | content |
|---|---|
| chemical name | Ondansetron hydrochloride |
| Molecular formula | C18H19N3O·HCl |
| Indications | Chemotherapy/radiation therapy-related nausea and vomiting, postoperative nausea and vomiting |
| Dosing method | Oral, intravenous, orally dissolving tablets |
2. Recent hot application scenarios
1.COVID-19 related vomiting treatment: Some studies show it may relieve gastrointestinal symptoms in COVID-19 patients.
2.Morning sickness management: Multinational guidelines recommend it for the second-line treatment of hyperemesis gravidarum.
3.Pediatric applications: Becoming one of the first-choice drugs for antiemetics during chemotherapy in children.
| Application areas | Usage proportion (2023 data) |
|---|---|
| Cancer Chemotherapy | 68% |
| Postoperative recovery | 22% |
| Other uses | 10% |
3. Side effects and precautions
According to the latest FDA warning:
- may causeQT interval prolongation, patients with heart disease should use with caution
- Common side effects include headache (15%), constipation (9%)
- Concomitant use with apomorphine may reduce the efficacy of the drug
| adverse reactions | incidence |
|---|---|
| headache | 15%-18% |
| constipation | 8%-10% |
| Lethargy | 5%-7% |
4. Market dynamics (hot spots in the past 10 days)
1.generic competition: A total of 12 domestic companies have passed the consistency evaluation
2.price fluctuations: The average price of 4mg tablets dropped to 2.3 yuan/tablet
3.Research and development of new dosage forms: Transdermal patch enters clinical phase III trial
| Manufacturing company | market share |
|---|---|
| Hengrui Medicine | 31% |
| Qilu Pharmaceutical | 25% |
| It's sunny | 18% |
5. Medication Guide
Standard dosage:
-before chemotherapy:8mg intravenous injection
-maintenance dose: 8 mg orally every 8 hours
Special groups:
- Patients with hepatic insufficiency need to reduce the dose by half
- No dose adjustment required in the elderly
Summary: Ondansetron hydrochloride, as a highly effective antiemetic, plays a key role in tumor treatment and other fields. The recent expansion of its application scope and the development of new dosage forms continue to attract attention, but the risk of cardiovascular side effects needs to be paid attention to when using the drug. It is recommended that patients use it under the guidance of a doctor.
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